Also known as Madame Hydra, Viper is one of the leading ladies of evil Marvel organizations. First appearing in 1969's Captain America #110, Viper has also had tangles with the mutant known as Logan and is therefore slated to appear in next years The Wolverine. Because of licensing issues (Marvel retains the rights to Hydra) this Viper will be named Victoria as opposed to the original name Ophelia. But this will not be Vipers first onscreen appearance.
Viper made her debut in the TV movie Nick Fury: Agent of SHIELD where she was named Andrea von Strucker, first lady of Hydra.
In 2003, Viper appeared on X-Men Evolution. In the episode Target X, it was revealed that Viper was involved with the creation of the Wolverine clone X-23.
Viper made her next appearance in Avengers: Earth's Mightiest Heroes where she was replaced by a Skrull before busting out of jail with Captain America and then leading the Serpent Society.